An outlook on suicide enzyme inhibition and drug design

There have been recent renewed interests in the importance of suicide enzyme inhibition. The principal objective this review is to investigate all types inhibitions for natural enzymes, artificial biocatalysts as well therapeutic potential It discussed inhibition beneficial drug design and treatments non-beneficial achievements some industrial enzymes such HRP peroxidase enzyme. biomimetic explained prevent by protecting active site via environmental conditions. Suicide development can be key mechanism against sever diseases SARS. In report, inactivation classes are classified based on target groups their substrates. substrate deceives its shape similarity normal after interaction with enzyme, suicidal functional group appears (e.g., Trojan horse).